치수에 염증 또는 괴사가 발생하면 보통 치근단 영역으로 확대되면서 치근단에 병소가 발생한다. 병소가 눈 아래쪽에 있는 제4전구치 뿌리에 발생하면 초반에는 염증성 농이 배출되지 못해 눈 밑이 부어오르고 농이 계속 축적되다 피부가 밖으로 터져서 나오게 되는 것이다.
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